Greenville is the largest city in and the seat of Greenville County, South Carolina, United States. The city's mayor is Knox White, who has been in that position since December 1995. With an estimated population of 67,453 as of 2016, it is the sixth-largest city in the state. The population of the surrounding area was 400,492 as of 2010, making it the third-largest urban area in South Carolina as well as the fastest growing. Greenville is the largest city in the Greenville-Anderson-Mauldin Metropolitan Statistical Area. The MSA had a population of 884,975 in 2016, making it the largest in South Carolina and the third largest in The Carolinas.Greenville is the largest city in the Greenville-Spartanburg-Anderson Combined Statistical Area. According to United States Census Bureau, the CSA had a population of 1,442,117 as of 2016, making it the largest CSA in the state. The CSA, a 10-county region of northwestern South Carolina, is known as "The Upstate".